F13B
coagulation factor XIII B chain
Normal Function
Health Conditions Related to Genetic Changes
Factor XIII deficiency
At least 17 mutations in the F13B gene have been found to cause inherited factor XIII deficiency, a rare bleeding disorder. Without treatment, affected individuals have a greatly increased risk of abnormal bleeding episodes, including life-threatening bleeding inside the skull (intracranial hemorrhage). F13B gene mutations severely reduce the amount or disrupt the function of the B subunit of factor XIII, preventing it from stabilizing and protecting the A subunit. The resulting loss of factor XIII activity weakens new blood clots and prevents them from stopping blood loss effectively.
More About This Health ConditionRelated Conditions
Factor XIII deficiencyAge-related macular degeneration
Health Conditions Related to Genetic Changes
At least 17 mutations in the F13B gene have been found to cause inherited factor XIII deficiency, a rare bleeding disorder. Without treatment, affected individuals have a greatly increased risk of abnormal bleeding episodes, including life-threatening bleeding inside the skull (intracranial hemorrhage). F13B gene mutations severely reduce the amount or disrupt the function of the B subunit of factor XIII, preventing it from stabilizing and protecting the A subunit. The resulting loss of factor XIII activity weakens new blood clots and prevents them from stopping blood loss effectively.
MedlinePlus Genetics provides information about Age-related macular degeneration