FGFR4

MedlinePlus Genetics provides information about Prostate cancer

A variation (polymorphism) in the FGFR4 gene that causes a switch in amino acids (the building blocks of proteins) is associated with several types of cancer, such as those that occur in the breast, colon, head and neck, and prostate. In people with this polymorphism, glycine is replaced by arginine at position 388 in the protein's chain of amino acids. This variation is common and appears to occur in about 50 percent of humans. Although it produces no ill effects in healthy people, the mutation is associated with accelerated disease progression in certain cancers.

The abnormal activation and increased activity of the FGFR4 gene are also implicated in the development of pituitary tumors and gastric, pancreatic, and ovarian cancers.