IL17RC
interleukin 17 receptor C
Normal Function
Health Conditions Related to Genetic Changes
Familial candidiasis
At least three mutations in the IL17RC gene have been identified in people with familial candidiasis, an inherited tendency to develop infections caused by the Candida fungus (commonly known as yeast infections). Most people with familial candidiasis have chronic yeast infections of the skin, nails, and mucous membranes (collectively called chronic mucocutaneous candidiasis) beginning in early childhood.
IL17RC gene mutations result in an absence of IL17RC receptor protein. Loss of this protein impairs binding of IL-17 cytokines and IL-17 signaling. This impaired signaling decreases production of the antimicrobial peptides and inflammatory molecules that are critical for defense against Candida, and results in the chronic infection that occurs in familial candidiasis.
More About This Health ConditionRelated Conditions
Familial candidiasis
Health Conditions Related to Genetic Changes
At least three mutations in the IL17RC gene have been identified in people with familial candidiasis, an inherited tendency to develop infections caused by the Candida fungus (commonly known as yeast infections). Most people with familial candidiasis have chronic yeast infections of the skin, nails, and mucous membranes (collectively called chronic mucocutaneous candidiasis) beginning in early childhood.
IL17RC gene mutations result in an absence of IL17RC receptor protein. Loss of this protein impairs binding of IL-17 cytokines and IL-17 signaling. This impaired signaling decreases production of the antimicrobial peptides and inflammatory molecules that are critical for defense against Candida, and results in the chronic infection that occurs in familial candidiasis.