IRGM
immunity related GTPase M
Normal Function
Health Conditions Related to Genetic Changes
Crohn's disease
Several variations in or near the IRGM gene have been associated with an increased risk of developing Crohn's disease. This increased risk has been found primarily in people of northern European ancestry. IRGM variations change single DNA building blocks (nucleotides) in regions of DNA that may regulate when and how the IRGM protein is produced. Researchers suspect that changes involving the IRGM protein may disrupt the autophagy process, preventing the immune system from destroying harmful bacteria effectively. An abnormal immune response to bacteria in the intestinal walls may lead to chronic inflammation and the digestive problems characteristic of Crohn's disease.
More About This Health ConditionRelated Conditions
Crohn's disease
Health Conditions Related to Genetic Changes
Several variations in or near the IRGM gene have been associated with an increased risk of developing Crohn's disease. This increased risk has been found primarily in people of northern European ancestry. IRGM variations change single DNA building blocks (nucleotides) in regions of DNA that may regulate when and how the IRGM protein is produced. Researchers suspect that changes involving the IRGM protein may disrupt the autophagy process, preventing the immune system from destroying harmful bacteria effectively. An abnormal immune response to bacteria in the intestinal walls may lead to chronic inflammation and the digestive problems characteristic of Crohn's disease.