STAT4
signal transducer and activator of transcription 4
Normal Function
Health Conditions Related to Genetic Changes
Systemic scleroderma
A normal variation in the STAT4 gene has been associated with an increased risk of developing systemic scleroderma, which is an autoimmune disorder characterized by the buildup of scar tissue (fibrosis) in the skin and internal organs. Although the STAT4 gene is known to stimulate the immune system in response to pathogens, it is unknown how the gene variation contributes to the increased risk of systemic scleroderma. Researchers believe that a combination of genetic and environmental factors may play a role in development of the condition.
More About This Health ConditionRelated Conditions
Systemic sclerodermaJuvenile idiopathic arthritisRheumatoid arthritisSystemic lupus erythematosusAutoimmune disorders
Health Conditions Related to Genetic Changes
A normal variation in the STAT4 gene has been associated with an increased risk of developing systemic scleroderma, which is an autoimmune disorder characterized by the buildup of scar tissue (fibrosis) in the skin and internal organs. Although the STAT4 gene is known to stimulate the immune system in response to pathogens, it is unknown how the gene variation contributes to the increased risk of systemic scleroderma. Researchers believe that a combination of genetic and environmental factors may play a role in development of the condition.
MedlinePlus Genetics provides information about Juvenile idiopathic arthritis
Studies have associated a normal variation in the STAT4 gene with an increased risk of rheumatoid arthritis. This condition is an autoimmune disorder, which occurs when the immune system malfunctions and attacks the body's tissues and organs.
The variant associated with increased risk of rheumatoid arthritis changes a single DNA building block (nucleotide) in the STAT4 gene. It is unknown how the gene variation contributes to increased risk of this condition. Researchers believe that a combination of genetic and environmental factors may play a role in development of autoimmunity.
Studies have associated a normal variation in the STAT4 gene with an increased risk of an autoimmune disorder called system lupus erythematosus.
The variant associated with increased risk of system lupus erythematosus changes a single nucleotide in the STAT4 gene. It is unknown how the gene variation contributes to increased risk of system lupus erythematosus. Researchers believe that a combination of genetic and environmental factors are likely involved in development of autoimmunity.
Studies have associated a normal variation in the STAT4 gene with an increased risk of an autoimmune disorder called Sjögren syndrome.
The variant associated with increased risk of this disorder changes a single nucleotide in the STAT4 gene. It is unknown how the gene variation contributes to increased risk of this condition. Researchers believe that a combination of genetic and environmental factors may play a role in disease development.